Placental tumor chorioangioma as a cause of polyhydramnios. On microscopic examination a well circumscribed lesion focally covered by membranes consisting of capillary sized vessels some solid and some with lumina lined by benign endothelial cells immunoreactive with cd31 and cd34 were seen. A large placental chorioangioma without an adverse perinatal. Small chorioangiomata are clinically insignificant and diagnosed after delivery. Chorioangioma definition of chorioangioma by medical. Chorioangioma in pregnancy miss surabhi bisht, dr ozlem turan, mr demetrios l economides, royal free hospital, london, uk. Placental chorioangioma as the cause of nonimmunologic. It is usually symptomless and may be associated with serious maternal and fetal complication when it reaches a large size. Prenatal diagnosis and fetomaternal outcomes of two cases. Pregnancies with large chorioangiomas are associated with maternal and fetal complications, such as growth restriction, cardiomegaly, congestive heart failure, fetal anemia, thrombocytopenia, nonimmune hydrops and intrauterine fetal death.
Antenatal diagnosis of chorioangioma of the placenta ba spirt, l gordon, wn cohen, t yambao american journal of roentgenology. The pathology of the human placenta, 3rd ed, springerverlag, new york 1995. Major problems in pathology, 2nd ed, wb saunders co, london 1997. Presenting a case of acute polyhydramnios with a large chorioangioma diagnosed antenatally on. Hamartomalike growth in the placenta consisting of blood vessels. We presented a case of an angiomatous type of placental hemangioma diagnosed in the second trimester of pregnancy in a patient with polyhydramnios. Professor s lakhani, dr j lowe, mr k miller, dr a rhodes, professor ra walker, dr ca wells. They may also sequester platelets and can, in turn, give a fetal thrombocytopenia.
The normal placenta is a round or ovalshaped organ that attaches to the uterine wall and has roughly 22 cm in diameter and a thickness of about 22. Pathology reporting of breast disease pdf 144p download book. Pathology of the human placenta, sixth edition request pdf. Background chorioangioma is the most common neoplasm of the placenta. Most chorioangiomas are small and are found incidentally at screening obstetric us examinations. Pathology of the placenta showed edema without signs of placental infarction and a big tumoral mass measuring 10. Most common tumor of the placenta incidence 1% rare tumors 2010. Congestive heart failure occurred early in the neonatal period as the main complication.
Chorangioma of the placenta is a rare tumor with a frequency of about 1%, which usually presents as a solitary nodule or, less frequently, as multiple nodules. Large placental chorioangioma as a cause of congestive. Microscopic examination revealed large fusiform vessels in a fibrotic stroma with focal edema and clusters of myxoid cells fig. Antenatal embolization of a large placental chorioangioma. Aug 12, 2018 chorangioma of placenta is a benign tumor of the placenta composed of blood vessels.
An important differential is intramuralsubmucosal fibroid, however intraplacental location and internal vascularity with feeding vessel, favor the diagnosis of chorioangioma. Large 4 cm chorioangiomas are much rarer and are often associated with maternal andor. Atypical chorangioma may be associated with increased cellularity, high mitotic activity, tumor necrosis, positive staining with factor viii antigen and may have large tumor size. It is mostly diagnosed ultrasonically in the second trimester of pregnancy. The significance of a chorangioma is determined by its size and. A patient with continuous abdominal pain at 29 weeks gestation was clinically diagnosed to have acute polyhydramnios. Placental chorioangioma is a nontrophoblastic benign tumor of the placenta that is characteristically vascular and originates from primitive chorionic tissue. Original communications chorioangioma of the placenta john h. Click download or read online button to get pathology of the placenta book now.
Placental chorioangioma radiology reference article. Large chorioangiomas can cause complications, including excess amniotic fluid polyhydramnios, maternal and fetal clotting problems coagulopathies, premature delivery, toxemia, fetal heart failure, and hydrops excess fluid that affect the fetus. Pathological analysis confirmed the diagnosis of placental chorioangioma. Introduction p lacental chorangioma described by clarke in 1789 is usually of pregnancies. Nineteen cases of placental chorioangioma were identified, including three twin pregnancies figure 1. The placental mass was a solid nodular tanbrown tissue 6 x 6. Request pdf pathology of the human placenta, sixth edition pathology of the.
Chorioangioma, originally described by clarke in 1798, is the most common tumor of the placenta, with reported prevalence of approximately 0. It is the most common tumor of the placenta the placenta is an organ that connects the developing fetus to the uterine wall. A chorangioma is a non neoplastic, hamartoma like growth in the placenta consisting of blood vessels. Most placental chorioangiomas are small in size and insignificant, but those that measure more than 4 to 5 cm in diameter increase the risk of complications for mother and fetus. Most chorioangiomas are small and they are diagnosed after delivery by careful sectioning of the placenta. Chorangioma is an uncommon pathology of the placenta that is similar to a hemangioma. Giant placental chorioangioma and polyhydramnios grande. They were more seen in multiple pregnancies and in female babies. Large chorioangiomas can cause complications, including excess amniotic fluid polyhydramnios, maternal and fetal clotting problems coagulopathies, premature delivery, toxemia, fetal heart failure, and hydrops excess fluid affecting the fetus.
Membrane formation and peripheral expansion 9 to 18 weeks from lmp. A patient with continuous abdominal pain at 29 weeks gestation was clinically. Fetal and perinatal pathology royal college of pathologists. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Tumors designated chorioangiomas, chorangiomas, fibroangiomyxomas, fibromas, and the many other. Chorioangioma of the placenta in association with early. The incidence of chorioangioma is about 1% of all births 1, 2.
From the department of pathology and bacteriology, university of western ontario medical school, london, ont. Case reports in obstetrics and gynecology volume 2012 2012, article id. Chorioangioma causes, symptoms, signs, diagnosis, treatment. The other 7 cases were identified prenatally as placental chorioangioma, at a mean menstrual age of 23 weeks and a mean maternal age of 29 years.
Chorioangioma is the most common benign placental tumor and frequent incidental finding in antenatal scans. Chorioangioma of the placenta is a rare cause of polyhydramnios which may be associated with adverse foetal outcome. Taylor obstetrical and gynaecological pathology 5th edn, foxh ed. Complete gross and histopathologic examination of the placenta should be obtained when clinically. Zanardini c, papageorghiou a, bhide a, thilaganathan b. It is rare and occurs in less than 1% of all pregnancies. Successful outcome of a pregnancy complicated by a. Objectives giant placental chorioangiomas are associ ated with a high. Introduction p lacental chorangioma described by clarke in 1789 is usually 5cm are rare, with prevalence ranging from 1.
From the obstetrical department and pathological laboratory of the buffalo childrens and general hospitals and the lnirersity of buffalo medical school w e wish to describe the gross and histologic findings in a case of a chorioangioma of the placenta. Chorioangiomas probably act as shunts between arteries and veins. The placental tissue revealed a fleshy nodular circumscribed lesion which is 10 cm. A chorioangioma is thought to arise as a malformation of the primitive angioblastic tissue of the placenta. Discussion placental chorioangioma is a benign vascular. Acute polyhydramnios and cord presentation complication of. To determine perinatal complications and pregnancy outcome in12 women with chorioangioma of placenta. Its incidence is quoted around 1 in 100 placentas and is seen more frequently in multiple pregnancies and in female babies. They speculated that the use of color doppler sonography. Nov 20, 2014 the pathogenesis of these neoplasms is controversial. Chorangioma of placenta is a benign tumor of the placenta composed of blood vessels.
This sixth edition of the book has been extensively revised and expanded to. Large chorioangioma has unfavourable effects on both mother and fetus. G we are intechopen, the worlds leading publisher of open access books. It however, lacks metastasis, invasion or biological aggressiveness. I will have to have more ultrasounds to make sure the baby is growing fine. It is found on the fetal surface of the placenta or in placental parenchyma. Successful outcome of a pregnancy complicated by a voluminous. The majority of pregnancies with chorioangiomas are asymptomatic. At the fetal center, an ultrasound was performed on mandi, revealing a large 6 cm chorioangioma arising only 2. Definition of chorioangioma, placental medicinenet.
Chorioangioma is believed to arise by 16th day of fertilization, although there is no documentation of the tumor in the first trimester. Large placental chorioangioma as a cause of congestive heart. Large tumors are rare and they often cause increased maternal morbidity and fetal morbidity and mortality. Pathology reporting of breast disease pdf 144p this contains some guideline which aim to encourage the use of common terminology and definitions of breast disease and to standardise methods of classification of breast cancer. Twelve cases of placental chorioangioma springerlink. Fetal echocardiography revealed the combined ventricular output to be 740 ml kilogram minute, which. Most chorangiomas are small and possess no clinical significance. Chorioangioma is a placental hemangioma which is a nontrophoblastic primary placental tumor. Most chorangiomas are not clinically significant, i.
Possibility of chorioangioma of placenta was considered. This guideline contains recommendations specific to twin and triplet pregnancies and covers the following clinical areas. I am 14 weeks along and just had an ultrasound yesterday diagnosing us with a chorioangioma. A careful antenatal ultrasound with colour doppler can easily diagnose the condition. We believe that all placentas should have a minimal examination including color, length of umbilical cord, number of cord vessels, and weight of the trimmed placental disk. Chorioangioma of the placenta is an uncommon benign tumor of the placenta. A chorioangioma is the most common benign tumor of the placenta. Full text placental tumor chorioangioma as a cause of. Chorioangioma is a benign angioma of placenta arising from chorionic tissue. Placental chorioangioma patient case study cincinnati. Since both maternal and neonatal complications may indicate premature termination of the pregnancy or be conducive to.
We describe a case with large chorioangioma that had a poor outcome on the fetus. Chorangioma of placenta with high risk pregnancy journal of basic and clinical reproductive sciences january june 2014 vol 3 issue 1 73 stated that the sonographic appearance of a chorioangioma was indistinguishable from that of a placental hemorrhage. Placental chorioangioma is the most common benign tumor of the placenta. Chorioangioma is a benign vascular tumor, found in approximately 1% of all pregnancies 50. Macroscopic examination of the placenta confirmed the presence of a chorioangioma in all cases, which was supported by microscopic examination, when performed n 15. This pathology is a malformation of the primitive angioblastic tissue of the placenta perfused by the fetal circulation. Placental chorioangioma is the most common type of placental tumor. Trophoblast proliferative units and placental growth to 40 weeks from. Voluminous chorangioma, placenta, pregnancy outcome. They vary from a few millimeters to 10 cm or more in rare cases. The placenta has an essential role in functions such as nutrition, excretion, and immunologic and endocrine function. A large placental chorioangioma without an adverse. Its a tumor between the placenta and umbilical cord.
Chorioangiomas may be diagnosed early in pregnancy by ultrasound examination. Since both maternal and neonatal complications may indicate premature termination of the pregnancy or be. Chorioangioma definition of chorioangioma by medical dictionary. Chorangioma of the placenta is considered to be a rare tumor of placenta with reported frequency is about 1% 3. During the period between january 1986 and december 1997, 12 women with histologic diagnosis of chorioangioma of placenta who delivered in our institution were studied. Chorioangioma is a benign vascular tumor of the placenta arising from primitive chorionic mesenchyme. A benign vascular blood vessel tumor of the placenta. The largest retrospective study of 22000 placental examinations showed 8 chorioangioma with an incidence of 0. Microscopic examination revealed benign mass composed of closely packed vascular spaces lined by endothelial cells and scanty loose intervening stroma. Introduction placental chorioangioma is the most common benign tumor of the placenta. Acute polyhydramnios and cord presentation complication. Placental pathology offers insight into both acute and chronic events.
Large chorioangiomas are known to cause complications in pregnancy, while the smaller ones are asymptomatic. The primary objective of this book is to be a concise, practical manual of placental. Physiologic and pathologic associations, pubertal and midlife changes, male reproductive function, the ovarian lifecycle, fertilization, early pregnancy and its disorders, infertility seminar, gynecologic disorders, clinical radiology in obgyn, physiology of normal labor and delivery, maternal physiology and prenatal care, clinical genetics, infectious diseases and aids, contraception or sexual differentiation. It occurs in up to 1% of all deliveries and most often goes unnoticed. This site is like a library, use search box in the widget to get ebook that you want. Rare findings include chorioangiomas, metastases, fetus. Sixty women with histologic examination of the placenta without.
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